RNA Gain-of-Function in Spinocerebellar Ataxia Type 8

Microsatellite expansions cause a number of dominantly-inherited neurological diseases. Expansions in coding-regions cause protein gain-of-function effects, while non-coding expansions produce toxic RNAs that alter RNA splicing activities of MBNL and CELF proteins. Bi-directional expression of the s...

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Hlavní autoři: Daughters, Randy S., Tuttle, Daniel L., Gao, Wangcai, Ikeda, Yoshio, Moseley, Melinda L., Ebner, Timothy J., Swanson, Maurice S., Ranum, Laura P. W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719092/
https://ncbi.nlm.nih.gov/pubmed/19680539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000600
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