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RNA Gain-of-Function in Spinocerebellar Ataxia Type 8
Microsatellite expansions cause a number of dominantly-inherited neurological diseases. Expansions in coding-regions cause protein gain-of-function effects, while non-coding expansions produce toxic RNAs that alter RNA splicing activities of MBNL and CELF proteins. Bi-directional expression of the s...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719092/ https://ncbi.nlm.nih.gov/pubmed/19680539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000600 |
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