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Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model
Normalization of tumor vasculature by antiangiogenic agents may improve the delivery of cytotoxic drugs to the tumor, leading to more effective therapy. In this study, we used pharmacokinetic and pharmacodynamic approaches to investigate how sunitinib at different dose levels affects brain distribut...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Duke University Press
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2718974/ https://ncbi.nlm.nih.gov/pubmed/18971416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-088 |
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