Antitumor effect in medulloblastoma cells by gefitinib: Ectopic HER2 overexpression enhances gefitinib effects in vivo

The effects of the epidermal growth factor receptor (EGFR) inhibitor gefitinib on cell growth and signaling were evaluated in three medulloblastoma (MB) cell lines (D283, D341, Daoy), one supratentorial primitive neuroectodermal tumor cell line (PFSK), and four MB primary cultures. Cell lines showed...

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Bibliographische Detailangaben
Hauptverfasser: Meco, Daniela, Servidei, Tiziana, Riccardi, Anna, Ferlini, Cristiano, Cusano, Gabriella, Zannoni, Gian Franco, Giangaspero, Felice, Riccardi, Riccardo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Duke University Press 2009
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718969/
https://ncbi.nlm.nih.gov/pubmed/19033425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-095
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