Antitumor effect in medulloblastoma cells by gefitinib: Ectopic HER2 overexpression enhances gefitinib effects in vivo

The effects of the epidermal growth factor receptor (EGFR) inhibitor gefitinib on cell growth and signaling were evaluated in three medulloblastoma (MB) cell lines (D283, D341, Daoy), one supratentorial primitive neuroectodermal tumor cell line (PFSK), and four MB primary cultures. Cell lines showed...

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Bibliographic Details
Main Authors: Meco, Daniela, Servidei, Tiziana, Riccardi, Anna, Ferlini, Cristiano, Cusano, Gabriella, Zannoni, Gian Franco, Giangaspero, Felice, Riccardi, Riccardo
Format: Artigo
Language:Inglês
Published: Duke University Press 2009
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718969/
https://ncbi.nlm.nih.gov/pubmed/19033425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-095
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