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Dynamic in Vivo Binding of STAT5 to Growth Hormone-Regulated Genes in Intact Rat Liver. Sex-Specific Binding at Low- But Not High-Affinity STAT5 Sites

Phylogenetic footprinting was used to predict functional transcription factor binding sites (TFBS) for signal transducer and activator of transcription (STAT) 5, a GH-activated transcription factor, in the GH-responsive genes IGF-I, SOCS2, and HNF6. Each gene, including upstream (100 kb) and downstr...

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Autori principali: Laz, Ekaterina V., Sugathan, Aarathi, Waxman, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Endocrine Society 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718744/
https://ncbi.nlm.nih.gov/pubmed/19423653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0449
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