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The effectiveness of position- and composition-specific gap costs for protein similarity searches
Motivation: The flexibility in gap cost enjoyed by hidden Markov models (HMMs) is expected to afford them better retrieval accuracy than position-specific scoring matrices (PSSMs). We attempt to quantify the effect of more general gap parameters by separately examining the influence of position- and...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2718649/ https://ncbi.nlm.nih.gov/pubmed/18586708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btn171 |
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