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The effectiveness of position- and composition-specific gap costs for protein similarity searches

Motivation: The flexibility in gap cost enjoyed by hidden Markov models (HMMs) is expected to afford them better retrieval accuracy than position-specific scoring matrices (PSSMs). We attempt to quantify the effect of more general gap parameters by separately examining the influence of position- and...

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Detalhes bibliográficos
Main Authors: Stojmirović, Aleksandar, Gertz, E. Michael, Altschul, Stephen F., Yu, Yi-Kuo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718649/
https://ncbi.nlm.nih.gov/pubmed/18586708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btn171
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