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Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
Makorin Ring Finger Protein 1 (MKRN1) is a transcriptional co-regulator and an E3 ligase. Here, we show that MKRN1 simultaneously functions as a differentially negative regulator of p53 and p21. In normal conditions, MKRN1 could destabilize both p53 and p21 through ubiquitination and proteasome-depe...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2718286/ https://ncbi.nlm.nih.gov/pubmed/19536131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.164 |
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