Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells

Hypoxia is well known to limit curability of tumors by ionizing radiation. Here, we show that hypoxia treatment of tumor cells causes coexpression of heat shock protein 70 (Hsp70) and phosphatidylserine (PS) on the cell surface. Colocalization of Hsp70 and PS, as determined by confocal microscopy, a...

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Detalhes bibliográficos
Main Authors: Schilling, Daniela, Gehrmann, Mathias, Steinem, Claudia, De Maio, Antonio, Pockley, Alan G., Abend, Michael, Molls, Michael, Multhoff, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717766/
https://ncbi.nlm.nih.gov/pubmed/19289606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-125229
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