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Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells

Hypoxia is well known to limit curability of tumors by ionizing radiation. Here, we show that hypoxia treatment of tumor cells causes coexpression of heat shock protein 70 (Hsp70) and phosphatidylserine (PS) on the cell surface. Colocalization of Hsp70 and PS, as determined by confocal microscopy, a...

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Bibliografiske detaljer
Main Authors: Schilling, Daniela, Gehrmann, Mathias, Steinem, Claudia, De Maio, Antonio, Pockley, Alan G., Abend, Michael, Molls, Michael, Multhoff, Gabriele
Format: Artigo
Sprog:Inglês
Udgivet: The Federation of American Societies for Experimental Biology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717766/
https://ncbi.nlm.nih.gov/pubmed/19289606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-125229
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