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The Activation Of ATM Depends On Chromatin Interactions Occurring Prior To DNA-Damage Induction

Efficient and correct responses to double stranded breaks (DSB) in chromosomal DNA are critical for maintaining genomic stability and preventing chromosomal alterations leading to cancer1. The generation of DSB is associated with structural changes in chromatin and the activation of the protein kina...

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Detalhes bibliográficos
Main Authors: Kim, Yong-Chul, Gerlitz, Gabi, Furusawa, Takashi, Catez, Frédéric, Nussenzweig, Andre, Oh, Kyu-Seon, Kraemer, Kenneth H., Shiloh, Yosef, Bustin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717731/
https://ncbi.nlm.nih.gov/pubmed/19079244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1817
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