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Heterozygous Kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function
OBJECTIVE: The evolutionarily conserved Kit receptor is vital for function of hematopoietic stem cells (HSC). Kit(W-41) (W-41) and Kit(W-42) (W-42) are single residue changes in the KIT intracellular phosphotransferase domain, while Kit(W-v) (W-v) is a single residue change in the ATP binding domain...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2717557/ https://ncbi.nlm.nih.gov/pubmed/17258070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2006.10.001 |
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