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Ion Selectivity in the KcsA Potassium Channel from the Perspective of the Ion Binding Site

To understand the thermodynamic exclusion of Na(+) relative to K(+) from the S(2) site of the selectivity filter, the distribution P(X)(ɛ) (X = K(+) or Na(+)) of the binding energy (ɛ) of the ion with the channel is analyzed using the potential distribution theorem. By expressing the excess chemical...

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Autori principali: Dixit, Purushottam D., Merchant, Safir, Asthagiri, D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717285/
https://ncbi.nlm.nih.gov/pubmed/19289040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.12.3917
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