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Fluid Shear Induces Conformation Change in Human Blood Protein von Willebrand Factor in Solution

Many of the physiological functions of von Willebrand Factor (VWF), including its binding interaction with blood platelets, are regulated by the magnitude of applied fluid/hydrodynamic stress. We applied two complementary strategies to study the effect of fluid forces on the solution structure of VW...

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Bibliographische Detailangaben
Hauptverfasser: Singh, Indrajeet, Themistou, Efrosyni, Porcar, Lionel, Neelamegham, Sriram
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2009
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717260/
https://ncbi.nlm.nih.gov/pubmed/19289057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.12.3900
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