Structural Differences between Aβ(1-40) Intermediate Oligomers and Fibrils Elucidated by Proteolytic Fragmentation and Hydrogen/Deuterium Exchange

The aggregation of amyloid-β protein (Aβ) in vivo is a critical pathological event in Alzheimer's disease. Although more and more evidence shows that the intermediate oligomers are the primary neurotoxic species in Alzheimer's disease, the particular structural features responsible for the...

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Bibliographic Details
Main Authors: Zhang, Aming, Qi, Wei, Good, Theresa A., Fernandez, Erik J.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2009
Subjects:
Protein
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716632/
https://ncbi.nlm.nih.gov/pubmed/19186145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.022
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