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Analysis of Helix-Helix Interactions of Bacteriorhodopsin by Replica-Exchange Simulations

We performed long-time replica-exchange Monte Carlo simulations of bacteriorhodopsin transmembrane helices, which made it possible that wide conformational space was sampled. Using only the helix-helix interactions and starting from random initial configurations, we obtained the nativelike helix arr...

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Bibliografske podrobnosti
Main Authors: Kokubo, Hironori, Okamoto, Yuko
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716567/
https://ncbi.nlm.nih.gov/pubmed/18835905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.129015
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