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WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth

INTRODUCTION: In breast cancer, deregulation of the WNT signaling pathway occurs by autocrine mechanisms. WNT ligands and Frizzled receptors are coexpressed in primary breast tumors and cancer cell lines. Moreover, many breast tumors show hypermethylation of the secreted Frizzled-related protein 1 (...

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Detalhes bibliográficos
Main Authors: Matsuda, Yutaka, Schlange, Thomas, Oakeley, Edward J, Boulay, Anne, Hynes, Nancy E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716500/
https://ncbi.nlm.nih.gov/pubmed/19473496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2317
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