Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium have been associated with selective MN degeneration, but...

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Main Authors: Jaiswal, Manoj Kumar, Zech, Wolf-Dieter, Goos, Miriam, Leutbecher, Christine, Ferri, Alberto, Zippelius, Annette, Carrì, Maria Teresa, Nau, Roland, Keller, Bernhard U
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716351/
https://ncbi.nlm.nih.gov/pubmed/19545440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-10-64
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