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Role of oxidative stress and AT(1) receptors in cerebral vascular dysfunction with aging

Vascular dysfunction occurs with aging. We hypothesized that oxidative stress and ANG II [acting via ANG II type 1 (AT(1)) receptors] promotes cerebral vascular dysfunction with aging. We studied young (5–6 mo), old (17–19 mo), and very old (23 ± 1 mo) mice. In basilar arteries in vitro, acetylcholi...

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Detalhes bibliográficos
Main Authors: Modrick, Mary L., Didion, Sean P., Sigmund, Curt D., Faraci, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716103/
https://ncbi.nlm.nih.gov/pubmed/19395552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00300.2009
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