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Dopamine Modulates Persistent Synaptic Activity and Enhances the Signal-to-Noise Ratio in the Prefrontal Cortex

BACKGROUND: The importance of dopamine (DA) for prefrontal cortical (PFC) cognitive functions is widely recognized, but its mechanisms of action remain controversial. DA is thought to increase signal gain in active networks according to an inverted U dose-response curve, and these effects may depend...

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Detalhes bibliográficos
Main Authors: Kroener, Sven, Chandler, L. Judson, Phillips, Paul E. M., Seamans, Jeremy K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715878/
https://ncbi.nlm.nih.gov/pubmed/19654866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006507
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