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Dopamine Modulates Persistent Synaptic Activity and Enhances the Signal-to-Noise Ratio in the Prefrontal Cortex

BACKGROUND: The importance of dopamine (DA) for prefrontal cortical (PFC) cognitive functions is widely recognized, but its mechanisms of action remain controversial. DA is thought to increase signal gain in active networks according to an inverted U dose-response curve, and these effects may depend...

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Autori principali: Kroener, Sven, Chandler, L. Judson, Phillips, Paul E. M., Seamans, Jeremy K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715878/
https://ncbi.nlm.nih.gov/pubmed/19654866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006507
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