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Large-scale chemical dissection of mitochondrial function

Mitochondrial oxidative phosphorylation (OXPHOS) is central to physiology and disease pathogenesis. To systematically investigate its activity and regulation, we performed a wide range of assays of OXPHOS physiology and nuclear and mitochondrial gene expression across 2490 chemical perturbations in...

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Detalhes bibliográficos
Main Authors: Wagner, Bridget K., Kitami, Toshimori, Gilbert, Tamara J., Peck, David, Ramanathan, Arvind, Schreiber, Stuart L., Golub, Todd R., Mootha, Vamsi K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715872/
https://ncbi.nlm.nih.gov/pubmed/18297058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1387
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