A Complicated Message: Identification of a Novel PB1-Related Protein Translated from Influenza A Virus Segment 2 mRNA

Influenza A virus segment 2 is known to encode two polypeptides in overlapping open reading frames: PB1, the polymerase, and PB1-F2, a proapoptotic virulence factor. We show that a third major polypeptide is synthesized from PB1 mRNA via differential AUG codon usage. PB1 codon 40 directs translation...

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Autori principali: Wise, Helen M., Foeglein, Agnes, Sun, Jiechao, Dalton, Rosa Maria, Patel, Sheetal, Howard, Wendy, Anderson, Emma C., Barclay, Wendy S., Digard, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715786/
https://ncbi.nlm.nih.gov/pubmed/19494001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00826-09
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