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Telavancin Disrupts the Functional Integrity of the Bacterial Membrane through Targeted Interaction with the Cell Wall Precursor Lipid II

Telavancin is an investigational lipoglycopeptide antibiotic currently being developed for the treatment of serious infections caused by gram-positive bacteria. The bactericidal action of telavancin results from a mechanism that combines the inhibition of cell wall synthesis and the disruption of me...

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Detalhes bibliográficos
Main Authors: Lunde, Christopher S., Hartouni, Stephanie R., Janc, James W., Mammen, Mathai, Humphrey, Patrick P., Benton, Bret M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715647/
https://ncbi.nlm.nih.gov/pubmed/19470513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01710-08
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