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Pyrazolopyrimidinediones Are Selective Agents for Helicobacter pylori That Suppress Growth through Inhibition of Glutamate Racemase (MurI)

Pyrazolopyrimidinediones are a novel series of compounds that inhibit growth of Helicobacter pylori specifically. Using a variety of methods, advanced analogues were shown to suppress the growth of H. pylori through the inhibition of glutamate racemase, an essential enzyme in peptidoglycan biosynthe...

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Autors principals: de Jonge, B. L. M., Kutschke, A., Uria-Nickelsen, M., Kamp, H. D., Mills, S. D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715633/
https://ncbi.nlm.nih.gov/pubmed/19433553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00226-09
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