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Pharmacokinetic/Pharmacodynamic Analysis of the Influence of Inoculum Size on the Selection of Resistance in Escherichia coli by a Quinolone in a Mouse Thigh Bacterial Infection Model

Maintaining quinolone concentrations outside the mutant selection window (MSW) between the MIC and mutant prevention concentration (MPC) was suggested by in vitro and in vivo studies to prevent the selection of resistant mutants. However, selection also may depend on the presence of resistant bacter...

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Detalhes bibliográficos
Main Authors: Ferran, Aude A., Kesteman, Anne-Sylvie, Toutain, Pierre-Louis, Bousquet-Mélou, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715583/
https://ncbi.nlm.nih.gov/pubmed/19487439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01347-08
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