Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists

Binding of the peptide hormone vasopressin to its type-2 receptor (V2R) in kidney triggers a cAMP-mediated translocation of Aquaporin-2 water channels to the apical membrane, resulting in water reabsorption and thereby preventing dehydration. Mutations in the V2R gene lead to Nephrogenic Diabetes In...

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Main Authors: Robben, Joris H., Kortenoeven, Marleen L. A., Sze, Mozes, Yae, Chris, Milligan, Graeme, Oorschot, Viola M., Klumperman, Judith, Knoers, Nine V. A. M., Deen, Peter M. T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715499/
https://ncbi.nlm.nih.gov/pubmed/19587238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900130106
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