Polyvalent Display of Heme on Hepatitis B Virus Capsid Protein through Coordination to Hexahistidine Tags

The addition of a hexahistidine tag to the N terminus of the hepatitis B capsid protein gives rise to a self-assembled particle with 80 sites of high local density of histidine side chains. Iron protoporphyrin IX has been found to bind tightly at each of these sites, making a polyvalent system of we...

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Autors principals: Prasuhn, Duane E., Kuzelka, Jane, Strable, Erica, Udit, Andrew K., Cho, So-Hye, Lander, Gabriel C., Quispe, Joel D., Diers, James R., Bocian, David F., Potter, Clint, Carragher, Bridget, Finn, M.G.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715361/
https://ncbi.nlm.nih.gov/pubmed/18482703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.03.018
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