Involvement of Calpain-Calpastatin in Cigarette Smoke–Induced Inhibition of Lung Endothelial Nitric Oxide Synthase

We reported that cigarette smoke extract (CSE) causes decreases in the activity and expression of endothelial nitric oxide synthase (eNOS) and calpain activity in pulmonary artery endothelial cells (PAECs). Calpains are a family of calcium-dependent endopeptidases, and their specific endogenous inhi...

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Detalhes bibliográficos
Main Authors: Cui, Zhaoqiang, Han, Zhaosheng, Li, Zhaozhong, Hu, Hanbo, Patel, Jawaharlal M., Antony, Veena, Block, Edward R., Su, Yunchao
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715359/
https://ncbi.nlm.nih.gov/pubmed/16100081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2005-0046OC
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