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A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice
In a phenotypic screen of the wild-derived mouse strain MOLF/Ei, we describe an earlier and more potent toll-like receptor (TLR)–mediated induction of IL-6 transcription compared with the classical inbred strain C57BL/6J. The phenotype correlated with increased activity of the IκB kinase axis as wel...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715079/ https://ncbi.nlm.nih.gov/pubmed/19564352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090490 |
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