CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids

The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only in mycobacteria, but its discovery raises the possibility that ribosomally pro...

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Detalhes bibliográficos
Main Authors: Van Rhijn, Ildiko, Young, David C., De Jong, Annemieke, Vazquez, Jenny, Cheng, Tan-Yun, Talekar, Rahul, Barral, Duarte C., León, Luis, Brenner, Michael B., Katz, Joel T., Riese, Richard, Ruprecht, Ruth M., O'Connor, Peter B., Costello, Catherine E., Porcelli, Steven A., Briken, Volker, Moody, D. Branch
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715062/
https://ncbi.nlm.nih.gov/pubmed/19468063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082480
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