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Role of lipid trimming and CD1 groove size in cellular antigen presentation

Cellular CD1 proteins bind lipids that differ in length (C(12−80)), including antigens that exceed the capacity of the CD1 groove. This could be accomplished by trimming lipids to a uniform length before loading or by inserting each lipid so that it penetrates the groove to a varying extent. New ass...

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Detalhes bibliográficos
Main Authors: Cheng, Tan-Yun, Relloso, Miguel, Van Rhijn, Ildiko, Young, David C, Besra, Gurdyal S, Briken, Volker, Zajonc, Dirk M, Wilson, Ian A, Porcelli, Steven, Moody, D Branch
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500985/
https://ncbi.nlm.nih.gov/pubmed/16794581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601185
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