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A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme
Many B cell cancers are characterized in part by the dysregulation of the NF-κB signaling pathway. A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-κB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas. These data reveal the role of A20 as a tumor supp...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2009
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715039/ https://ncbi.nlm.nih.gov/pubmed/19380636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090765 |
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