TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

Proliferation and survival of Hodgkin and Reed/Sternberg (HRS) cells, the malignant cells of classical Hodgkin lymphoma (cHL), are dependent on constitutive activation of nuclear factor κB (NF-κB). NF-κB activation through various stimuli is negatively regulated by the zinc finger protein A20. To de...

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Hlavní autoři: Schmitz, Roland, Hansmann, Martin-Leo, Bohle, Verena, Martin-Subero, Jose Ignacio, Hartmann, Sylvia, Mechtersheimer, Gunhild, Klapper, Wolfram, Vater, Inga, Giefing, Maciej, Gesk, Stefan, Stanelle, Jens, Siebert, Reiner, Küppers, Ralf
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2009
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715030/
https://ncbi.nlm.nih.gov/pubmed/19380639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090528
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