Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1

We recently developed a novel strategy to identify transmitted HIV-1 genomes in acutely infected humans using single-genome amplification and a model of random virus evolution. Here, we used this approach to determine the molecular features of simian immunodeficiency virus (SIV) transmission in 18 e...

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Detalhes bibliográficos
Main Authors: Keele, Brandon F., Li, Hui, Learn, Gerald H., Hraber, Peter, Giorgi, Elena E., Grayson, Truman, Sun, Chuanxi, Chen, Yalu, Yeh, Wendy W., Letvin, Norman L., Mascola, John R., Nabel, Gary J., Haynes, Barton F., Bhattacharya, Tanmoy, Perelson, Alan S., Korber, Bette T., Hahn, Beatrice H., Shaw, George M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715022/
https://ncbi.nlm.nih.gov/pubmed/19414559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082831
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