A Multicenter Study of Cancer Incidence in CHEK2 1100delC Mutation Carriers

The CHEK2 1100delC protein-truncating mutation has a carrier frequency of ~0.7% in Northern and Western European populations and confers an ~2-fold increased risk of breast cancer. It has also been suggested to increase risks of colorectal and prostate cancer, but its involvement with these or other...

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Auteurs principaux: Thompson, Deborah, Seal, Sheila, Schutte, Mieke, McGuffog, Lesley, Barfoot, Rita, Renwick, Anthony, Eeles, Rosalind, Sodha, Nayanta, Houlston, Richard, Shanley, Susan, Klijn, Jan, Wasielewski, Marijke, Chang-Claude, Jenny, Futreal, P. Andrew, Weber, Barbara L., Nathanson, Katherine L., Stratton, Michael, Meijers-Heijboer, Hanne, Rahman, Nazneen, Easton, Douglas F.
Format: Artigo
Langue:Inglês
Publié: 2006
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714971/
https://ncbi.nlm.nih.gov/pubmed/17164383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-06-0687
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