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Reverse Engineering of the Spindle Assembly Checkpoint
The Spindle Assembly Checkpoint (SAC) is an intracellular mechanism that ensures proper chromosome segregation. By inhibiting Cdc20, a co-factor of the Anaphase Promoting Complex (APC), the checkpoint arrests the cell cycle until all chromosomes are properly attached to the mitotic spindle. Inhibiti...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714964/ https://ncbi.nlm.nih.gov/pubmed/19652707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006495 |
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