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Pak3 inhibits local actin filament formation to regulate global cell polarity
Lamellipodia are broad actin-based structures that define the protruding edge of many motile animal cells. Here we identify a Drosophila homolog of the p21-activated kinases (Paks) as a novel inhibitor of Rac-mediated lamellipodial formation: Pak3 overexpression mimics a loss of Rac activity, while...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
HFSP Publishing
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714956/ https://ncbi.nlm.nih.gov/pubmed/19639041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2976/1.3100548 |
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