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Development of a Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry Method for Analysis of Stable 4-Hydroxyequilenin-DNA Adducts in Human Breast Cancer Cells

Estrogen-DNA adducts are potential biomarkers for assessing cancer risk and progression in estrogen-dependent cancer. 4-Hydroxyequilenin (4-OHEN), the major catechol metabolite of equine estrogens present in hormone replacement therapy formulations, autoxidizes to a reactive o-quinone that subsequen...

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Autores principales: Wang, Zhican, Edirisinghe, Praneeth, Sohn, Johann, Qin, Zhihui, Geacintov, Nicholas E., Thatcher, Gregory R. J., Bolton, Judy L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714912/
https://ncbi.nlm.nih.gov/pubmed/19368368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900063g
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