Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

Nicotine dependence risk and lung cancer risk are associated with variants in a region of chromosome 15 encompassing genes encoding the nicotinic receptor subunits CHRNA5, CHRNA3 and CHRNB4. To identify potential biological mechanisms that underlie this risk, we tested for cis-acting eQTLs for CHRNA...

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Bibliografski detalji
Glavni autori: Wang, Jen C., Cruchaga, Carlos, Saccone, Nancy L., Bertelsen, Sarah, Liu, Pengyuan, Budde, John P., Duan, Weimin, Fox, Louis, Grucza, Richard A., Kern, Jason, Mayo, Kevin, Reyes, Oliver, Rice, John, Saccone, Scott F., Spiegel, Noah, Steinbach, Joseph H., Stitzel, Jerry A., Anderson, Marshall W., You, Ming, Stevens, Victoria L., Bierut, Laura J., Goate, Alison M.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2009
Teme:
Association Studies Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714722/
https://ncbi.nlm.nih.gov/pubmed/19443489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp231
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