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Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction

The advent of targeted therapies for cancer has provoked interest in experimental models for the systematic study of oncogene dependence. To that end, we developed a three-dimensional (3D) culture system to analyze the responses of primary mouse mammary epithelial cells to the induction and deinduct...

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Hlavní autoři: Jechlinger, Martin, Podsypanina, Katrina, Varmus, Harold
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714708/
https://ncbi.nlm.nih.gov/pubmed/19605689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1801809
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