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Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress

We report that 9 d of uncontrolled experimental diabetes induced by streptozotocin (STZ) in rats is an endogenous chronic stressor that produces retraction and simplification of apical dendrites of hippocampal CA3 pyramidal neurons, an effect also observed in nondiabetic rats after 21 d of repeated...

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發表在:Proc Natl Acad Sci U S A
Principais autores: Magariños, Ana María, McEwen, Bruce S.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2000
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在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27147/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11005876/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.20.11056
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