Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris

BACKGROUND: VAR2CSA is the main candidate for a vaccine against pregnancy-associated malaria, but vaccine development is complicated by the large size and complex disulfide bonding pattern of the protein. Recent X-ray crystallographic information suggests that domain boundaries of VAR2CSA Duffy bind...

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Detalhes bibliográficos
Main Authors: Avril, Marion, Hathaway, Marianne J, Cartwright, Megan M, Gose, Severin O, Narum, David L, Smith, Joseph D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714522/
https://ncbi.nlm.nih.gov/pubmed/19563628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-8-143
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