Evidence for Globally Shared, Cross-Reacting Polymorphic Epitopes in the Pregnancy-Associated Malaria Vaccine Candidate VAR2CSA

Pregnancy-associated malaria (PAM) is characterized by the placental sequestration of Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin sulfate A (CSA). VAR2CSA is a leading candidate for a pregnancy malaria vaccine, but its large size (∼350 kDa) and extensive...

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Autori principali: Avril, Marion, Kulasekara, Bridget R., Gose, Severin O., Rowe, Chris, Dahlbäck, Madeleine, Duffy, Patrick E., Fried, Michal, Salanti, Ali, Misher, Lynda, Narum, David L., Smith, Joseph D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292848/
https://ncbi.nlm.nih.gov/pubmed/18250177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01470-07
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