Mice that lack activity of αvβ6- and αvβ8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

The arginine-glycine-aspartate (RGD)-binding integrins αvβ6 and αvβ8 activate latent TGFβ1 and TGFβ3 in vivo, but it is uncertain whether other RGD-binding integrins such as integrins αvβ5 and αvβ3 activate these TGFβ isoforms. To define the combined role of αvβ6- and αvβ8-integrin in TGFβ activatio...

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Main Authors: Aluwihare, Poshala, Mu, Zhenyu, Zhao, Zhicheng, Yu, Dawen, Weinreb, Paul H., Horan, Gerald S., Violette, Shelia M., Munger, John S.
Formato: Artigo
Idioma:Inglês
Publicado: Company of Biologists 2009
Assuntos:
Short Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714418/
https://ncbi.nlm.nih.gov/pubmed/19118215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.035246
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