The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

The EGFR/PI3K/Akt/mTOR signaling pathway is activated in many cancers including glioblastoma, yet mTOR inhibitors have largely failed to show efficacy in the clinic. Rapamycin promotes feedback activation of Akt in some patients, potentially underlying clinical resistance and raising the need for al...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Guo, Deliang, Hildebrandt, Isabel J., Prins, Robert M., Soto, Horacio, Mazzotta, Mary M., Dang, Julie, Czernin, Johannes, Shyy, John Y.-J., Watson, Andrew D., Phelps, Michael, Radu, Caius G., Cloughesy, Timothy F., Mischel, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714280/
https://ncbi.nlm.nih.gov/pubmed/19625624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906606106
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados