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Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines

BACKGROUND: The Hedgehog (HH) pathway promotes tumorigenesis in a diversity of cancers. Activation of the HH signaling pathway is caused by overexpression of HH ligands or mutations in the components of the HH/GLI1 cascade, which lead to increased transactivation of GLI transcription factors. Althou...

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Autors principals: Mizuarai, Shinji, Kawagishi, Aki, Kotani, Hidehito
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714036/
https://ncbi.nlm.nih.gov/pubmed/19575820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-44
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