Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy

BACKGROUND: Epigenetic silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) by promoter methylation is associated with improved survival in glioblastomas treated with alkylating agents. In this study, we investigated MGMT promoter methylation in glioblastomas treated with temozolomide and ra...

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Detalhes bibliográficos
Main Authors: Dunn, J, Baborie, A, Alam, F, Joyce, K, Moxham, M, Sibson, R, Crooks, D, Husband, D, Shenoy, A, Brodbelt, A, Wong, H, Liloglou, T, Haylock, B, Walker, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713697/
https://ncbi.nlm.nih.gov/pubmed/19536096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605127
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