Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy

BACKGROUND: Epigenetic silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) by promoter methylation is associated with improved survival in glioblastomas treated with alkylating agents. In this study, we investigated MGMT promoter methylation in glioblastomas treated with temozolomide and ra...

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Détails bibliographiques
Auteurs principaux: Dunn, J, Baborie, A, Alam, F, Joyce, K, Moxham, M, Sibson, R, Crooks, D, Husband, D, Shenoy, A, Brodbelt, A, Wong, H, Liloglou, T, Haylock, B, Walker, C
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2009
Sujets:
Molecular Diagnostics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713697/
https://ncbi.nlm.nih.gov/pubmed/19536096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605127
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