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Enhanced development of CD4(+) γδ T cells in the absence of Itk results in elevated IgE production
The Tec kinase Itk is critical for the development of αβ T cells as well as differentiation of CD4(+) T cells into Th2 cells. Itk null mice have defects in the production of Th2 cytokines; however, they paradoxically have significant elevations in serum IgE. Here we show that Itk null mice have incr...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713465/ https://ncbi.nlm.nih.gov/pubmed/19443662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-196345 |
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