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Heterochromatinization as a Potential Mechanism of Nickel-Induced Carcinogenesis

Epigenetics refers to heritable patterns of gene expression that do not depend on alterations of the genomic DNA sequence. Nickel compounds have demonstrated carcinogenicity without any associated mutagenesis, suggesting that its mechanism of carcinogenesis is epigenetic in nature. One such potentia...

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Detalhes bibliográficos
Main Authors: Ellen, Thomas P., Kluz, Thomas, Harder, Mark E., Xiong, Judy, Costa, Max
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713359/
https://ncbi.nlm.nih.gov/pubmed/19338343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900246h
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