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An Allosteric Modulator of α7 Nicotinic Receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), Causes Conformational Changes in the Extracellular Ligand Binding Domain Similar to Those Caused by Acetylcholine

Nicotinic acetylcholine receptors are implicated in several neuropsychiatric disorders, including nicotine addiction, Alzheimer's, schizophrenia, and depression. Therefore, they represent a critical molecular target for drug development and targeted therapeutic intervention. Understanding the m...

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Detalhes bibliográficos
Main Authors: Barron, Sean C., McLaughlin, James T., See, Jennifer A., Richards, Vanessa L., Rosenberg, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713121/
https://ncbi.nlm.nih.gov/pubmed/19411608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.056226
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